Does the order of exercises in a session change what a lifter gains? Three papers answer this with data: a 2021 meta-analysis of 11 studies, a 2019 randomised trial in 36 young men and a 2020 randomised trial in 44 older women. This guide reads their PubMed abstracts on 4 November 2026. Full texts were not used, so only what the abstracts report is covered. The papers say nothing about particular equipment, and this guide makes no claim about dumbbells or kettlebells. General information, not advice.
What is being compared?
All three papers compare two orders of the same session. In one, multi-joint (MJ) exercises come first and single-joint (SJ) exercises follow (written MJ-SJ). In the other the order is reversed (SJ-MJ). The abstracts use these labels without listing which exercises were in each group, and “pre-exhaustion” appears among the keywords of the 2021 meta-analysis and the 2019 trial.
What did the pooled analysis of 11 studies find?
The meta-analysis by Nunes and colleagues, in the European Journal of Sport Science in 2021, searched four databases, included 11 studies rated of good-to-excellent methodological quality on the TESTEX checklist, and pooled them with a random-effects model using Hedges’ g as the effect size (ES). Its results depend on which measure is looked at:
- All strength tests combined, in both multi-joint and single-joint exercises: no difference between the orders (ES minus 0.11, p = 0.306).
- Strength gains in the multi-joint exercises: a difference favouring starting with multi-joint exercises (ES 0.32, p = 0.034).
- Strength gains in the single-joint exercises: a difference favouring starting with single-joint exercises (ES minus 0.58, p = 0.032).
- Muscle hypertrophy, combining site-specific and indirect measures: no significant effect of order (ES 0.03, p = 0.862).
The authors conclude that increases in muscular strength are the largest in the exercises performed at the beginning of a session, and that for hypertrophy both orders may produce similar results.
What happened over 6 weeks in 36 young men?
In the 2019 trial by Avelar and colleagues (Applied Physiology, Nutrition, and Metabolism), 36 young men were randomly assigned to a 6-week programme in the order MJ-SJ (19 men) or SJ-MJ (17 men). Muscle thickness was measured by ultrasound and lean soft tissue by dual-energy X-ray absorptiometry.
- Biceps brachii thickness rose similarly in both groups: plus 14.2% for MJ-SJ and plus 13.8% for SJ-MJ.
- Only the MJ-SJ group showed an increase in mid-thigh thickness from before to after training: plus 7.2%, against plus 3.9% for SJ-MJ.
- Upper limb lean soft tissue was statistically similar between the groups (plus 5.2% and plus 7.5%), trunk lean soft tissue showed a trend (P = 0.07, plus 7.2% and plus 1.7%), and lower limb changes were nonsignificant.
The authors suggest both sequences are effective for muscle hypertrophy over a short-term programme, with a possibly beneficial effect for the mid-thigh from progressing from MJ to SJ exercises.
And over 12 weeks in older women?
The 2020 trial by Tomeleri and colleagues (Journal of Strength and Conditioning Research) randomised 44 older women to a nonexercise control group (15) or to a 12-week programme in the order MJ-SJ (14) or SJ-MJ (15). The programme ran three times a week with 8 exercises of 3 sets of 10 to 15 repetitions each. Strength was tested by one repetition maximum, and lean soft tissue was estimated by dual-energy X-ray absorptiometry.
Both training groups showed significant and similar increases in strength (16.4% for MJ-SJ, 12.7% for SJ-MJ) and mass (7.5% and 6.1%), and testosterone and insulin-like growth factor 1 showed no significant changes. The authors say the results suggest both approaches are similarly effective in this group.
Do the three results agree?
They measure different things, so they are not contradictions. The meta-analysis looks at strength in the exercises themselves and at hypertrophy overall. The 2019 trial measured muscle size at particular sites in young men over 6 weeks, the 2020 trial measured strength and lean mass in older women over 12 weeks. The abstracts do not say whether either trial is one of the 11 studies in the meta-analysis. A result in young men does not describe older women, and the reverse.
What the abstracts leave open
The abstracts do not report results by level of training, for periods longer than 12 weeks, or for particular loads, and they do not say how any one person should arrange a session. The mid-thigh finding in the 2019 trial comes from one site in one small group and is described by its authors as a possible effect.
The bottom line
The 2021 meta-analysis of 11 studies found no difference between the two orders when all strength tests were combined, larger strength gains in whichever type of exercise was done first, and no significant effect of order on hypertrophy. The 2019 trial in young men found similar biceps growth with both orders and a possible mid-thigh advantage for starting with multi-joint exercises. The 2020 trial in older women found similar strength and mass gains with both orders. Because the studies differ in people, measures and length, each result describes its own sample and measure.
Sources
- What influence does resistance exercise order have on muscular strength gains and muscle hypertrophy? A systematic review and meta-analysis, Nunes and colleagues, European Journal of Sport Science, February 2021 (abstract, PubMed), read 4 November 2026 (pubmed.ncbi.nlm.nih.gov)
- Effects of order of resistance training exercises on muscle hypertrophy in young adult men, Avelar and colleagues, Applied Physiology, Nutrition, and Metabolism, April 2019 (abstract, PubMed), read 4 November 2026 (pubmed.ncbi.nlm.nih.gov)
- Influence of Resistance Training Exercise Order on Muscle Strength, Hypertrophy, and Anabolic Hormones in Older Women: A Randomized Controlled Trial, Tomeleri and colleagues, Journal of Strength and Conditioning Research, November 2020 (abstract, PubMed), read 4 November 2026 (pubmed.ncbi.nlm.nih.gov)








